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KMID : 0857020060210010364
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Kosin Medical Journal
2006 Volume.21 No. 1 p.364 ~ p.368
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Adaptation of neurovasculature on brain in chronic sublethal hypoxia Roles of neurotrophic factor
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Kim Kang-Ryune
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Abstract
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Hypoxia episodes of prenatal and perinatal brain are causes of significant long-term neurologic morbidity, mental retardation, seizures, and cerebral palsy, owing to the neuronal cell death, attributable to either necrosis or apoptosis. Also preterm birth is associated with significant neurological disability and chronic hypoxia. In chronic hypoxia, vascular growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) function in neurovasculature by prominent angiogenesis and block of neuronal apoptosis. BDNF, a family of neurotrophic factors has roles of neuroprotection and neural growth, axonal guidance, through the activation of tyrosine receptor kinases B (TrkB) receptor. Also BDNF rescues brain-derived endothelial cells from hypoxic damage,and induces angiogenesis in hypoxic cultured model. Moreover ther are some possibilities of ’cross-talk of signaling’ between BDNF and VEGF. These studies suggest that BDNF and VEGF are candidates for the pharmacological intervention in hypoxic neuronal injury.
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KEYWORD
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Chronic sublethal hypoxia, Neuron, vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), Tyrosine receptor kinase B (TrkB)
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